Studies on tolerance to ganglionic blocking agents in man; reversal of depressor action of quaternary ammonium compounds.
نویسندگان
چکیده
منابع مشابه
Pharmacological Properties of a Bis-quaternary Ammonium Salt of the Dibenzo-bicyclo(2.2.2) Octane Series, Especially Its Depressant Effect on the Muscle Spindle.
松下 亨 The present investigation was performed in order to clarify the mechanism of ataxic behavior following the administration of 2-(3-dimethylaminopropyl)-1,3,3a,4,9,9a-hexa hydro-4,9-o-benzeno-2H-benz[f]isoindole dimethiodide (MI-65-S) to mammals. For several years, many bis-quaternary ammonium salts containing a bicyclo(2.2.2) octane ring in their large cationic head have been synthesized in...
متن کاملTOXICOLOGICAL STUDIES ON CERTAIN AMINOALKYL ETHERS AS POTENTIAL LONG-ACTING LOCAL ANAESTHETICS
The acute intravenous toxicities of a selection of three potential long-acting local anaesthetics belonging to the series of2- phenoxyethyldialkylamine were determined in mice. Two of the compounds were tertiary amines and the third a quaternary ammonium derivative.The I.V. median lethal dose, (LDso) of one of the tertiary compounds, 21A [N, N- diethyl-2- (2,6- diisopropyl) ethyl amine hyd...
متن کاملGraded reduction of arterial pressure in man by means of a thiophanium derivative (Ro 2-2222); preliminary observations on its effect in acute pulmonary edema.
The authors describe the use of a ganglionic blocking agent which acts almost entirely as a peripheral vasodilator with minimal side effects in man. This substance acts almost instantaneously when given intravenously, with the depressor effect quantitatively controlled by regulating the infusion rate without tachyphylaxis over several hours. Depressor effect of the drug disappears 2 to 15 minut...
متن کاملA new orally active quaternary ammonium, ganglion blocking drug capable of reducing blood pressure, Su-3088.
Experiments were performed in animals to evaluate 4,5,6,7-tetrachloro-2-(2 dimethylaminoethyl)-isoindoline dimethochloride, (Su-3088), as an orally effective ganglion blocking drug. These demonstrated reduction of blood pressure, suppression of vasopressor reflexes and potentiation of the pressor action of epinephrine. Neostigmine deblocked drug effects and returned responses toward normal. Exp...
متن کاملAB INITIO QUANTUM CHEMICAL STUDIES IN CTAB
Quaternary ammonium compounds (QACS) are employed both as disinfectants for manual processing lines and surfaces in the food industry, and in human medicine area. QACS also cause cell death by protein denaturation . One of the QAC is cetyl trimethyl ammonium bromide (CTAB) that appears to rapture the cell membrane. The primary site of action of CTAB has been suggested to be the lipid components...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation
دوره 10 6 شماره
صفحات -
تاریخ انتشار 1954